Spike glycoprotein
S蛋白是一個很大的三聚體跨膜糖蛋白，它在病毒表面形成特殊的花冠結構，得名于其獨特的形狀，即一系列突出的棘刺。S蛋白含有兩個功能亞基：S1和S2。S1亞基中有兩個基本結構域，稱為受體結合域（RBD）和N端域（NTD）。S2具有三個域，分別稱為Heptad Repeat（HR）、Central Helix（CH）和Connector Domain（CD）。S蛋白的主要功能是幫助病毒進入和感染宿主細胞。它通過與宿主細胞表面的特定受體結合來實現這一點。在SARS-CoV-2的情況下，S蛋白與人體細胞表面的ACE2受體結合，從而啟動感染過程。S1亞基負責識別并結合宿主細胞表面的受體，而S2亞基則負責將病毒包膜與宿主細胞膜融合，使病毒內的遺傳物質得以注入細胞，達到感染的目的。 S蛋白的信號通路主要涉及其與宿主細胞受體的相互作用和膜融合過程。當S蛋白的RBD區域與宿主細胞表面的ACE2受體結合后，會觸發一系列的細胞內信號傳導事件。這些事件可能涉及細胞內的多種分子和通路，最終導致病毒包膜與宿主細胞膜的融合，以及病毒遺傳物質的釋放和感染過程的完成。全面地理解S蛋白在病毒感染過程中的作用機制，有利于開發針對冠狀病毒的疫苗和抗病毒藥物提供關鍵信息。
熱銷產品
● Recombinant Severe acute respiratory syndrome coronavirus 2 Spike glycoprotein (S), partial (Active)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Predicted band size: 51.1 kDa
Observed band size: 66 kDa due to glycosylation
Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2-S1-RBD at 2 μg/ml can bind Biotinylated Anti-SARS-CoV-2-S Antibody (CSB-RA33245D1GMY), the EC50 of SARS-CoV-2-S1-RBD protein is 106.2-131.2 ng/ml.
Measured by its binding ability in a functional ELISA. Immobilized human ACE2 (CSB-MP866317HU) at 2 μg/ml can bind SARS-CoV-2-S1-RBD, the EC50 of SARS-CoV-2-S1-RBD protein is 8.363-12.82 ng/ml.
● Recombinant Human SARS coronavirus Spike glycoprotein (S), partial (Active)
驗證數據
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 2 μg/ml can bind Paguma larvata ACE2 (CSB-MP684964PAL), the EC50 is 5.056-7.559 ng/ml.
Activity: Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV S-RBD at 5 μg/ml can bind human ACE2 (CSB-MP866317HU), the EC50 is 7.941-10.49 ng/ml.
Spike glycoprotein Antibodies
Spike glycoprotein for Human coronavirus OC43
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA336163EA01HIY | S Antibody | Human coronavirus OC43 | ELISA |
Spike glycoprotein for Bovine coronavirus
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-PA333052LA01BJO | S Antibody | Bovine coronavirus | ELISA |
| CSB-PA333052LC01BJO | S Antibody, FITC conjugated | Bovine coronavirus | |
| CSB-PA333052LD01BJO | S Antibody, Biotin conjugated | Bovine coronavirus | ELISA |
Spike glycoprotein for Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV)
| 產品貨號 | 產品名稱 | 種屬反應性 | 應用類型 |
|---|---|---|---|
| CSB-RA33245A0GMY | S Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA |
| CSB-RA33245A1GMY | S Recombinant Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA, Neutralising |
| CSB-RA33245B1GMY | S Recombinant Monoclonal Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-RA33245C1GMY | S Recombinant Monoclonal Antibody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | |
| CSB-RA33245D1GMY | S Recombinant Monoclonal Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-RA33245A2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA, GICA, Neutralising |
| CSB-EAP33245 | SARS-CoV-2 Spike RBD Antibody Pair 1 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
| CSB-RA33245B2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-RA33245C2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-RA33245D2GMY | SARS-CoV-2 Spike RBD Recombinant Nanobody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-MA33245A2m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-MA33245A1m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-MA33245A0m | S Monoclonal Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-PA33245YA01GMY | S Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-PA33245YD01GMY | S Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-PA33245YA11GMY | S Antibody | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-PA33245YB11GMY | S Antibody, HRP conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-PA33245YC11GMY | S Antibody, FITC conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | |
| CSB-PA33245YD11GMY | S Antibody, Biotin conjugated | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | ELISA |
| CSB-EAP33255A1 | SARS-CoV-2 N Antibody Pair 1 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
| CSB-EAP33255A2 | SARS-CoV-2 N Antibody Pair 2 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
| CSB-EAP33255A3 | SARS-CoV-2 N Antibody Pair 3 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
| CSB-EAP33255A4 | SARS-CoV-2 N Antibody Pair 4 | Human Novel Coronavirus (SARS-CoV-2/ 2019-nCoV) | S-ELISA |
Spike glycoprotein Proteins
Spike glycoprotein Proteins for Human coronavirus 229E (HCoV-229E)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP321366HIT CSB-BP321366HIT CSB-MP321366HIT CSB-EP321366HIT-B |
Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | Yeast Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP321366HIT | Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | E.coli |
| CSB-MP321366HIT1 | Recombinant Human coronavirus 229E Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein Proteins for Bos taurus (Bovine)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP333052BJO | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | Yeast |
| CSB-EP333052BJO | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | E.coli |
Spike glycoprotein Proteins for Human coronavirus OC43 (HCoV-OC43)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Yeast |
| CSB-MP336163HIY CSB-EP336163HIY-B |
Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | E.coli |
| CSB-EP336163HIY1 | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | E.coli |
| CSB-BP336163HIY | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Baculovirus |
| CSB-MP336163HIY1 | Recombinant Human coronavirus OC43 Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein Proteins for Human SARS coronavirus (SARS-CoV) (Severe acute respiratory syndrome coronavirus)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP348663HQE CSB-BP348663HQE CSB-EP348663HQE-B |
Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | E.coli Baculovirus In Vivo Biotinylation in E.coli |
| CSB-MP348663HQE | Recombinant Severe acute respiratory syndrome coronavirus Spike glycoprotein (S), partial (Active) | Mammalian cell |
| CSB-YP348663HQE | Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | Yeast |
| CSB-YP348663HQEa4 | Recombinant Human SARS coronavirus Spike glycoprotein (S), partial | Yeast |
Spike glycoprotein Proteins for Human coronavirus HKU1 (isolate N5) (HCoV-HKU1)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-YP607323HIW CSB-BP607323HIW CSB-EP607323HIW-B |
Recombinant Human coronavirus HKU1 Nucleoprotein (N) | Yeast Baculovirus In Vivo Biotinylation in E.coli |
| CSB-EP607323HIW | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | E.coli |
| CSB-EP607323HIWc7 | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | E.coli |
| CSB-MP607323HIW | Recombinant Human coronavirus HKU1 Nucleoprotein (N) | Mammalian cell |
Spike glycoprotein Proteins for Human coronavirus NL63 (HCoV-NL63)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-EP747509HIX CSB-BP747509HIX CSB-MP747509HIX CSB-EP747509HIX-B |
Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | E.coli Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-YP747509HIX1 | Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | Yeast |
| CSB-YP747509HIX | Recombinant Human coronavirus NL63 Spike glycoprotein (S), partial | Yeast |
Spike glycoprotein Proteins for Bovine coronavirus (strain vaccine) (BCoV) (BCV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-BP333052BJO CSB-MP333052BJO CSB-EP333052BJO-B |
Recombinant Bovine coronavirus Spike glycoprotein (S), partial | Baculovirus Mammalian cell In Vivo Biotinylation in E.coli |
| CSB-EP333052BJOc7 | Recombinant Bovine coronavirus Spike glycoprotein (S), partial | E.coli |
Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) (SARS-CoV-2)
Spike glycoprotein Proteins for Severe acute respiratory syndrome coronavirus (SARS-CoV)
| 產品貨號 | 產品名稱 | 來源 |
|---|---|---|
| CSB-MP348663HQEc7 | Recombinant Severe acute respiratory syndrome coronavirus Spike glycoprotein (S), partial | Mammalian cell |
Spike glycoprotein ELISA Kit
Spike glycoprotein ELISA Kit for Homo sapiens (Human)
| 產品貨號 | 產品名稱 | 樣本類型 | 靈敏度 |
|---|---|---|---|
| CSB-EL33241HU | Human SARS-CoV-2 S1 RBD IgG Antibody ELISA Kit | serum, plasma | |
| CSB-EL33242HU | Human SARS-CoV-2 S1 RBD IgM Antibody ELISA Kit | serum, plasma |
